John S. (Pete) Lollar ||| , M.D.
Dr. Lollar received his medical degree at St. Louis University and underwent residency and fellowship training in Internal Medicine and Hematology & Oncology at the University of Iowa and at the Mayo Clinic. He has conducted research on the structure and function of the factor VIII - von Willebrand factor complex, the assembly of the intrinsic pathway factor X activation complex, the immune response to factor VIII and the biosynthesis of factor VIII. He is the inventor of Obizur, a recombinant factor VIII product used to treat individuals with inhibitory antibodies to factor VIII. He currently is Hemophilia of Georgia Professor of Pediatrics at Emory University.
Mohan Rao, Ph.D.
Chief Executive Officer
Dr. Mohan Rao is the Chief Executive Officer of Expression Therapeutics LLC. In 2018, he was recognized by the Intellectual Asset Magazine (IAM) as “among the foremost experts when it comes to pharmaceutical economics.” Dr. Rao also serves as the Chief Executive Officer of Epsilon Economics which provides economic analysis to leading global pharmaceutical, biotechnology, and medical devices companies. Prior to Epsilon Economics, he managed Navigant Economics, a global economics consulting firm. Dr. Rao is an Adjunct Professor in Engineering Management at Northwestern University where he was appointed as the first “Executive in Residence” -- a recognized leader in the technology community –- by the McCormick College of Engineering. He was previously a professor at UCLA and a Teaching Fellow at Harvard University. He has a Bachelor of Science in Engineering from the University of Michigan, a pre-doctoral fellowship from Harvard University, and a Ph.D. from the University of Colorado. Dr. Rao serves on the Board of Directors of the Children's Hospital of Chicago, the Stanley Manne Children's Research Institute, and the Economic Club of Chicago, on the Board of Trustees of the Rotary/One Foundation, the Chicago Symphony Orchestra, and North Shore Country Day, and is a member of the Chicago Club.
H. Trent Spencer, Ph.D.
Dr. Spencer received his Ph.D. in Biochemistry from Creighton School of Medicine in Omaha. His postdoctoral studies at St. Jude Children's Research Hospital focused on drug resistance gene therapy and in vivo selection of genetically-modified cells. He is currently the Jean R. Amos Cell and Gene Therapy Chair, Director of the Cell and Gene Therapy Program and Professor of Pediatrics within the Aflac Cancer and Blood Disorders Center at Emory University. His previous affiliations include an Assistant Professorship in the South Carolina Cancer Center/Department of Biological Sciences, University of South Carolina and Assistant Director of the Molecular Genetics Graduate Program. He has headed a well-funded gene therapy laboratory for over 20 years. His research interests continue to be the development of gene therapy applications for the treatment of cancer and inherited diseases.
Christopher B. Doering, Ph.D.
Chief Scientific Officer
Dr. Doering received his B.S. in zoology from the University of Texas, Austin and his Ph.D. in genetics and molecular biology from Emory University. Chris has a longstanding interest in coagulation factor VIII biology stemming from his postdoctoral studies characterizing recombinant porcine, murine and bioengineered factor VIII molecules. Currently, he is Professor of Pediatrics in the Aflac Cancer and Blood Disorders Center. As a trained molecular biologist and experimental hematologist with more than 20 years of research experience in gene and protein expression, his overall scientific interest has centered on the development of gene therapy and protein engineering strategies for genetic diseases and cancers. Current areas of research involve the development of pharmaceutically-inspired coagulation factors, general approaches to viral vector genome engineering, and cancer gene therapy approaches involving genetically-engineered innate immune cells as well as exotic chimeric antigen receptors. Within the past few years, his lab has published articles in Nature Biotechnology, Nature Communications, Molecular Therapy, Blood, and Journal of Thrombosis and Hemostasis.
Gabriela Denning, Ph.D
Vice President of Research & Development
Dr. Denning received her Ph.D. in Biochemistry from The University of Texas Medical Branch. Her post-doctoral studies at The Scripps Research Institute under Dr. Peter K. Vogt, focused on understanding novel mechanisms of PTEN tumor suppressor function. Currently, Dr. Denning oversees all pre-clinical research and development efforts at Expression Therapeutics. Dr. Denning oversees many company roles including directing the development and execution of NIH STTR and SBIR funded programs in lentiviral and adeno-associated viral gene therapy of hemophilia A as well as recombinant ET3i immune tolerance induction for FVIII inhibitors.
Vice President, Manufacturing
Mr. Swaney is the Vice President of Manufacturing at Expression Therapeutics and is a renowned expert in vector manufacturing. He has three decades of experience in biopharmaceutical manufacturing of viral vectors for use in human clinical trials and has conducted over 70 GMP runs for academic and commercial clients. He was previously the Director of the Vector Production Facility & Viral Vector Core at the Cincinnati Children’s Hospital Medical Center. Prior to that, he served as the Operations Director of the Biologic Therapy Core Facility at the Washington University School of Medicine in St. Louis, Missouri, as the Senior Operations Manager of the cGMP Stem Cell Laboratory at the Tulane University Health Sciences Center in New Orleans, LA, and as the Quality Assurance Manager for the Human Gene Therapy Applications Laboratory at the University of Pittsburgh in Pennsylvania. Mr. Swaney received his M.S. in Human Genetics from the University of Pittsburgh Graduate School of Public Health. His thesis studied mechanisms to enhance retroviral mediated gene transfer into human hematopoietic stem cells by pretreatment of the RV supernatant with cationic liposomes and spinoculation of the HSC and RV liposome pre-treated supernatant. His research interests continue to be improved & scalable manufacturing platforms for different viral vectors and recently includes the successful manufacture of individualized patient specific products for the treatment of cancer.